Jesus as Lord in the Synoptic Gospels

Thesis (M.A.)--Boston UniversityThe various uses of "Lord" for Jesus in the Synoptic Gospels suggest that there were differences in the sources used by the authors as well as differences of opinion as to the significance of the title. Since the word might have come from either the Judaic or the Hellenistic culture, the determination of the predominant influence would help to assign meanings to ambiguous uses in the text and would shed light on the Christology of the primitive church. The method used in this study was twofold: an analysis of the uses of "Lord" in the Gospels, and a study of the cultural environments which might have influenced the Gospel writers. For the textual analysis, the relevant passages were isolated and grouped in Gospel units. The choice of passages was based on the incidence of a form of kurios in the Greek text and the specific or implied relation of the passage to the historic or the exalted Jesus. The passages were then put in tables to facilitate comparison with the other Gospels. [TRUNCATED

Why NIPT should be publicly funded

Asking pregnant women to (co)pay for non-invasive prenatal testing (NIPT) out of pocket leads to unequal access across socioeconomic strata. To avoid these social justice issues, first-trimester prenatal screening should be publicly funded in countries such as the Netherlands, with universal coverage healthcare systems that offer all other antenatal care

Zinserhöhung der EZB: Wie groß ist die Inflationsgefahr?

Für Thomas Mayer, Deutsche Bank, erscheint es sinnvoll, dass die EZB den Leitzins auf sein neutrales Niveau hochführt. Noch wichtiger für die Wahrung der Stabilität des Euro wäre es aber, dass sich die EZB aus der Finanzierung von durch Insolvenz bedrohten Staaten und ihren Banken zurückzieht. Holger Schmieding, Berenberg Bank, sieht keine Inflationsgefahr. Er rechnet für Deutschland mit einem jährlichen Preisanstieg von gut 2%. Manfred Jäger-Ambroz.ewicz, Institut der deutschen Wirtschaft Köln, vertritt die Meinung, dass die EZB eine sachgerechte Leitzinspolitik umsetzt und einen angemessenen Leitzinspfad suggeriert. Michael Lamla und Jan-Egbert Sturm, ETH Zürich, betonen, dass die EZB genügend Glaubwürdigkeit und Transparenz besitzt, um die Inflationserwartungen zu beeinflussen und zu homogenisieren. Ihrer Ansicht nach steigen insgesamt die Inflationserwartungen im Euroraum für das nächste Jahr weiterhin an, ohne aber beunruhigende Werte anzunehmen. Auch Ulrich Kater, DekaBank, sieht die Glaubwürdigkeit des Inflationsregimes mit der Geldwertstabilität als wichtigster Zielsetzung unabhängiger Notenbanken nicht gefährdet. Leon Leschus, HWWI, geht davon aus, dass hohe Rohstoffpreise weiterhin zum Inflationsdruck beitragen werden. Es wäre somit wünschenswert, wenn die EZB ihre begonnene restriktive Geldpolitik fortsetzen würde. Hans Wolfgang Brachinger, Universität Fribourg, sieht angesichts teurer Rohstoffe, zunehmender Spekulation und steigender Produktionskosten in China die Inflationsrisiken in Deutschland wachsen, und zwar unabhängig vom Handeln der EZB.Preisniveaustabilität, Geldpolitik, Zins, Zinspolitik, Inflation, Zentralbank, Europäische Wirtschafts- und Währungsunion

The effectiveness of ibrutinib in chronic lymphocytic leukaemia: a nationwide, population-based study in the Netherlands

Contains fulltext : 218321.pdf (Publisher’s version ) (Closed access

Should pregnant women be charged for non-invasive prenatal screening? Implications for reproductive autonomy and equal access

The introduction of non-invasive prenatal testing (NIPT) in healthcare systems around the world offers an opportunity to reconsider funding policies for prenatal screening. In some countries with universal access healthcare systems, pregnant women and their partners are asked to (co)pay for NIPT. In this paper, we discuss two important rationales for charging women for NIPT: (1) to

High-throughput Proteomics Identifies THEMIS2 as Independent Biomarker of Treatment-free Survival in Untreated CLL

It remains challenging in chronic lymphocytic leukemia (CLL) to distinguish between patients with favorable and unfavorable time-to-first treatment (TTFT). Additionally, the downstream protein correlates of well-known molecular features of CLL are not always clear. To address this, we selected 40 CLL patients with TTFT ≤24 months and compared their B cell intracellular protein expression with 40 age- and sex-matched CLL patients with TTFT &gt;24 months using mass spectrometry. In total, 3268 proteins were quantified in the cohort. Immunoglobulin heavy-chain variable (IGHV) mutational status and trisomy 12 were most impactful on the CLL proteome. Comparing cases to controls, 5 proteins were significantly upregulated, whereas 3 proteins were significantly downregulated. Of these, only THEMIS2, a signaling protein acting downstream of the B cell receptor, was significantly associated with TTFT, independently of IGHV and TP53 mutational status (hazard ratio, 2.49 [95% confidence interval, 1.62-3.84]; P &lt; 0.001). This association was validated on the mRNA and protein level by quantitative polymerase chain reaction and ELISA, respectively. Analysis of 2 independently generated RNA sequencing and mass spectrometry datasets confirmed the association between THEMIS2 expression and clinical outcome. In conclusion, we present a comprehensive characterization of the proteome of untreated CLL and identify THEMIS2 expression as a putative biomarker of TTFT.</p

Implementing non-invasive prenatal testing (NIPT) in the Netherlands: An interview study exploring opinions about and experiences with societal pressure, reimbursement, and an expanding scope

The noninvasive prenatal test (NIPT) as the first trimester prenatal screening (FTS) for trisomies 21, 18, and 13 is offered to all pregnant women in the Netherlands. NIPT using genome sequencing allows for an expansion of the scope of FTS and the introduction of NIPT gives rise to ethical and societal concerns about deliberated decision-making, pressure to engage in screening, and possible lack of equal access due to the financial contribution (€175) to NIPT. We explored the opinions and experiences of pregnant women, who were offered FTS, about these concerns, and the possibility of a broadened scope. Nineteen pregnant women representing a diversity of backgrounds were interviewed using a semi-structured interview guide. Eight women did not opt for prenatal screening while 11 did (NIPT = 4, combined test = 7). Women experienced a free choice to accept or decline prenatal screening, despite sometimes receiving advice from others. Prior to pretest counseling, some women had already deliberated about what an abnormal test result would mean to them. Others accepted or declined FTS without deliberation. The current Dutch policy of requiring a co-payment was acceptable to some, who believed that it functioned as a threshold to think carefully about FTS. Others were concerned that a financial threshold would lead to unequal access to screening. Finally, pregnant women found it difficult to formulate opinions on the scope of FTS, because of lack of knowledge. Life expectancy, severity, and treatability were considered important criteria for the inclusion of a condition in NIPT

Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases:Multidisciplinary Consensus Document from the COLLISION Trial Group

The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a 'toolbox' of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability and ablatability criteria for the treatment of colorectal liver metastases (CRLM). To pursue consensus, members of the multidisciplinary COLLISION and COLDFIRE trial expert panel employed the RAND appropriateness method (RAM). Statements regarding patient, disease, tumor and treatment characteristics were categorized as appropriate, equipoise or inappropriate. Patients with ECOG≤2, ASA≤3 and Charlson comorbidity index ≤8 should be considered fit for curative-intent local therapy. When easily resectable and/or ablatable (stage IVa), (neo)adjuvant systemic therapy is not indicated. When requiring major hepatectomy (stage IVb), neo-adjuvant systemic therapy is appropriate for early metachronous disease and to reduce procedural risk. To downstage patients (stage IVc), downsizing induction systemic therapy and/or future remnant augmentation is advised. Disease can only be deemed permanently unsuitable for local therapy if downstaging failed (stage IVd). Liver resection remains the gold standard. Thermal ablation is reserved for unresectable CRLM, deep-seated resectable CRLM and can be considered when patients are in poor health. Irreversible electroporation and stereotactic body radiotherapy can be considered for unresectable perihilar and perivascular CRLM 0-5cm. This consensus document provides per-patient and per-tumor resectability and ablatability criteria for the treatment of CRLM. These criteria are intended to aid tumor board discussions, improve consistency when designing prospective trials and advance intersociety communications. Areas where consensus is lacking warrant future comparative studies.</p

Enriching Music with Synchronized Lyrics, Images and Colored Lights

We present a method to synchronize popular music with its lyrics at the stanza level. First we apply an algorithm to segment audio content into harmonically similar and/or contrasting progressions, i.e. the stanzas. We map the stanzas found to a sequence of labels, where stanzas with a similar progression are mapped to the same label. The lyrics are analyzed as well to compute a second sequence of labels. Using dynamic programming, an optimal match is found between the two sequences, resulting in a stanzalevel synchronization of the lyrics and the audio. The synchronized lyrics can be used to compute a synchronized slide show to accompany the music, where the images are retrieved using the lyrics. For an additional enrichment of the experience, colored light effects are synchronized with the music that are computed from the sets of images. The song segmentation can be done reliably, while the mapping of the audio segments and lyrics gives encouraging results. Categories and Subject Descriptor

Rethinking counselling in prenatal screening: An ethical analysis of informed consent in the context of non-invasive prenatal testing (NIPT)

Informed consent is a key condition for prenatal screening programmes to reach their aim of promoting reproductive autonomy. Reaching this aim is currently being challenged with the introduction of non-invasive prenatal testing (NIPT) in first-trimester prenatal screening programmes: amongst others its procedural ease—i